Journal article

The effect of continuous hemofiltration on acid-base physiology

HK Tan, R Bellomo

Current Opinion in Critical Care | Published : 1999


Continuous hemofiltration techniques have a powerful effect on acid-base physiology. In patients with metabolic acidosis, hemofiltration techniques replace plasma water, which is low in bicarbonate concentration, with a solution, which contains either an above-normal bicarbonate concentration or a high concentration of a multi-carbon anion (lactate or acetate). Such anions are then transformed into CO2 which is removed by ventilation. This exchange contributes to the correction of acidosis. The conventional view of such changes in acid-base balance is that lactate and acetate correct acidosis by generating bicarbonate. An emerging view, however, is that such oxidizable anions probably alkali..

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University of Melbourne Researchers

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