Journal article

Use of adsorptive mechanisms in continuous renal replacement therapies in the critically ill

C Tetta, R Bellomo, A Brendolan, P Piccinni, A Digito, M Dan, M Irone, G Lonnemann, D Moscato, J Buades, G La Greca, C Ronco

Kidney international. Supplement | BLACKWELL SCIENCE INC | Published : 1999

Abstract

The pathophysiology of sepsis is becoming a more complicated scenario. In sepsis, endotoxin or other gram-positive derived products induce a complex and dynamic cellular response giving rise to several mediators known to be relevant in the pathogenesis of septic shock, such as specific mediators. substances responsible for up- or down-regulation of cytokine receptors and cytokine antagonists, inactivators of nuclear factor-kappaB or signal transduction pathways, and precursor molecules. In this article, we delve into some new concepts stemming from the use of sorbents in continuous plasma filtration. The rationale is based on the assumption that the nonspecific removal of several mediators o..

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University of Melbourne Researchers