Journal article
Youth Depression Alleviation-Augmentation with an anti-inflammatory agent (YoDA-A): protocol and rationale for a placebo-controlled randomized trial of rosuvastatin and aspirin
AL Quinn, OM Dean, CG Davey, M Kerr, SM Harrigan, SM Cotton, AM Chanen, S Dodd, A Ratheesh, GP Amminger, M Phelan, A Williams, A Mackinnon, F Giorlando, S Baird, S Rice, M O'Shea, MR Schäfer, E Mullen, S Hetrick Show all
Early Intervention in Psychiatry | WILEY | Published : 2018
DOI: 10.1111/eip.12280
Abstract
Aim: There is growing support for the role of inflammation and oxidative stress in the pathophysiology of major depressive disorder (MDD). This has led to the development of novel strategies targeting inflammation in the treatment of depression. Rosuvastatin and aspirin have well-documented, anti-inflammatory and antioxidant properties. The aim of the Youth Depression Alleviation: Augmentation with an anti-inflammatory agent (YoDA-A) study is to determine whether individuals receiving adjunctive anti-inflammatory agents, aspirin and rosuvastatin experience a reduction in the severity of MDD compared with individuals receiving placebo. Methods: YoDA-A is a 12-week triple-blind, randomized con..
View full abstractRelated Projects (1)
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The study is supported by a National Health and Medical Research Project Grant and the Investigators are grateful for this support. We would also like to gratefully acknowledge the contributions of Rachel Brodie, Danijela Piskulic, Toni Scaffidi, Natalie Ferguson, Suzanne Wiltink, Lisa Incerti, Alexandra Parker, and Ben Harrison. We would also like to acknowledge the service providers and their staff including Orygen, The National Centre of Excellence in Youth Mental Health, the relevant Headspace sites and Barwon Health. CGD is funded by an NHMRC Clinical Career Development Fellowship (APP1061757). MB is supported by a NHMRC Senior Principal Research Fellowship (1059660). SR is supported by an Early Career Fellowship from the Society of Mental Health Research.