Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways
Marta Martin-Subero, George Anderson, Buranee Kanchanatawan, Michael Berk, Michael Maes
CNS SPECTRUMS | CAMBRIDGE UNIV PRESS | Published : 2016
The nature of depression has recently been reconceptualized, being conceived as the clinical expression of activated immune-inflammatory, oxidative, and nitrosative stress (IO&NS) pathways, including tryptophan catabolite (TRYCAT), autoimmune, and gut-brain pathways. IO&NS pathways are similarly integral to the pathogenesis of inflammatory bowel disease (IBD). The increased depression prevalence in IBD associates with a lower quality of life and increased morbidity in IBD, highlighting the role of depression in modulating the pathophysiology of IBD.This review covers data within such a wider conceptualization that better explains the heightened co-occurrence of IBD and depression. Common IO&..View full abstract
Awarded by NHMRC
M. B. is supported by a NHMRC Senior Principal Research Fellowship 1059660. M. M. wants to thank the Fundacion Espanola de Psiquiatria y Salud Mental.