Journal article

Hyponatraemia: An Audit of Aged Psychiatry Patients Taking SSRIs and SNRIs

Francesco Giorlando, Julia Teister, Seetal Dodd, Marc Udina, Michael Berk

Current Drug Safety | BENTHAM SCIENCE PUBL | Published : 2013


OBJECTIVE: Hyponatraemia is a serious adverse event commonly reported in elderly people treated with serotonergic antidepressants. The mechanism, incidence and risk factors for antidepressant induced hyponatraemia are not fully understood. METHOD: In a retrospective chart analysis, depressed patients aged >63 years were investigated for change in serum sodium levels between two time points, separated by a median period of 45.5 days, with the first specimen taken prior to treatment. Patients were grouped into three cohorts; treated with an SSRI or SNRI (n=77), treated with an antidepressant other than an SSRI or SNRI (n=54) and not treated with an antidepressant (n=128). RESULTS: For change i..

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