Journal article

Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlation

Clarissa Severino Gama, Michael Berk, Ana Cristina Andreazza, Flavio Kapczinski, Paulo Belmonte-de-Abreu

Brazilian Journal of Psychiatry | ASSOC BRASILEIRA PSIQUIATRIA | Published : 2008


OBJECTIVE: The neurotrophins, antioxidant enzymes and oxidative markers have reciprocal interactions. This report verified in chronically stable medicated schizophrenic patients whether there are correlations between the serum levels of superoxide dismutase, a key enzyme in the antioxidant defense, thiobarbituric acid reactive substances, a direct index of lipid peroxidation, and brain-derived neurotrophic factor, the most widely distributed neurotrophin. METHOD: Sixty DSM-IV schizophrenic patients were included (43 males, 17 females). Mean age was 34.7 +/- 10.8 years, mean age at first episode was 19.8 +/- 7.9 years, and mean illness duration was 14.9 +/- 8.5 years. Each subject had a blood..

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