Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model

Huanli Sun; Mattias Bjoernmalm; Jiwei Cui; Edgar HH Wong; Yunlu Dai; Qiong Dai; Greg G Qiao; Frank Caruso

Journal article

Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model

Huanli Sun, Mattias Bjoernmalm, Jiwei Cui, Edgar HH Wong, Yunlu Dai, Qiong Dai, Greg G Qiao, Frank Caruso

ACS MACRO LETTERS | AMER CHEMICAL SOC | Published : 2015

DOI: 10.1021/acsmacrolett.5b00591

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Abstract

Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular processing. Herein, we develop soft polysaccharide (hyaluronic acid, HA) replica particles and capsules with tunable stiffness and sizes similar to human red blood cells (RBCs) via atom transfer radical polymerization-mediated continuous assembly of polymers (CAPATRP) and investigate their stiffness and deformability using colloidal-probe atomic force microscopy (CP-AFM) and a microfluidic blood capillary model, respectively. We demonstrate that HA replica particles and capsules with comparable nanoscale stiffness exhibit significantly different behaviors in a microflui..

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University of Melbourne Researchers

Frank Caruso Author Chemical Engineering

Jiwei Cui Author Chemical Engineering

Greg Qiao Author Chemical Engineering

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology

Awarded by ARC under the Australian Laureate Fellowship

Awarded by ARC under the Future Fellowship

Awarded by ARC under the Discovery Project

Awarded by ARC under the Super Science Fellowship

Funding Acknowledgements

This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036). This work was also supported by the ARC under the Australian Laureate Fellowship (FL120100030, F.C.), Future Fellowship (FT110100411, G.G.Q), Discovery Project (DP1094147 and DP130101846, F.C. and G.G.Q), and Super Science Fellowship (FS110200025, F.C. and G.G.Q.,) schemes, as well as the Australian Government through an Australian Postgraduate Award (M.B.). We acknowledge Martin P. van Koeverden for providing the ATRP macroinitiator and Junling Guo, Katelyn T. Gause, and Dr. Biao Kong for helpful discussions. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF).