Risk factors for development of flucloxacillin associated jaundice

Abstract

Objectives - To identify risk factors predisposing to the development of flucloxacillin associated jaundice. Design - Case-control study. Medical records of cases and controls were reviewed and information recorded on standard data collection forms. Setting - Alfred Hospital recruiting subjects from Melbourne, Sydney, and Brisbane. Subjects - Cases were defined as patients who had developed jaundice within eight weeks of stopping flucloxacillin, biochemical test results suggesting cholestasis, normal calibre bile ducts, and not been taking recognised hepatotoxic drugs. 51 of the 53 patients referred were included in the study. Four controls for each case were randomly selected from the patie..