Engineering Nanomedicines to Overcome Multidrug Resistance in Cancer Therapy
GL Berettab, F Cavalieri
Current Medicinal Chemistry | Bentham Science Publishers | Published : 2016
Drug resistance to conventional antitumor drugs still remains one of the major causes of treatment failure in patients affected by tumors. Two main types of drug resistance to anticancer drugs can be recognized in tumors, intrinsic resistance, in which tumor cells are inherent resistant to chemotherapy and acquired resistance, as a result of previous drug exposure. Tumor cells resistant to a chemotherapeutic agent became cross-resistant to both similar and structurally unrelated classes of antitumor drugs, a biological mechanism known as multi drug resistance (MDR). Among the strategies considered to overcome MDR, nanovector-mediated drug administration represents an innovative and promising..View full abstract
All individuals listed as authors have contributed substantially to the collections and discussions of the reported published work. This work was supported in part by Future Fellowship 2014 (F. Cavalieri FT140100873).