Journal article

Michael-type addition reactions for the in situ formation of poly(vinyl alcohol)-based hydrogels

Mariarosaria Tortora, Francesca Cavalieri, Ester Chiessi, Gaio Paradossi



Michael-type addition reactions offer the possibility to obtain in situ formation of polymeric hydrogels in the absence of a radical mechanism for the networking process. We explored such a synthetic route for obtaining a poly(vinyl alcohol) (PVA)-based hydrogel as a potential biomaterial for applications in vitro-retinal replacement surgery. The presence of radicals in the reaction medium can represent a risk for in situ surgical treatment. To circumvent this problem we have applied nucleophilic addition to ad hoc modified PVA macromers. The gel formation has been studied with respect to the timing required in this surgery and in terms of the structural characteristics of the obtained netwo..

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University of Melbourne Researchers