Journal article

Inhibited fragmentation of mAbs in buffered ionic liquids

Romiza R Mazid, R Vijayaraghavan, Douglas R MacFarlane, Christina Cortez-Jugo, Wenlong Cheng

Chemical Communications | ROYAL SOC CHEMISTRY | Published : 2015

Abstract

We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.

University of Melbourne Researchers