CHILDREN WITH INTRACTABLE FOCAL EPILEPSY: ICTAL AND INTERICTAL 99TcVi HMPAO SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY

Abstract

Fourteen children with intractable complex partial seizures underwent ictal and interictal 99TCM HMPAO single photon emission computed tomography (SPECT) scans. Abnormalities concordant with clinical and/or FEG localisation were present in 13 of 14 ictal and/or interictal scans. Focal hyperpertusion was seen at the seizure focus on ictal scans and focal hypoperfusion was seen on interictal scans. The timing of the injection in relation to the start of the seizure was crucial for reliable localisation. While recognisable patterns of regional cerebral blood flow (rCBF) were seen on either interictal or ictal scans, marked changes in the patterns of rCBF between the ictal study and interictal s..