Interictal 99Tc(m) HMPAO SPECT and 1H MRS in children with temporal lobe epilepsy

Abstract

Purpose: To understand the pathological basis of focal hypoperfusion seen on interictal 99Tcm hexamethylpropyleneamine oxime (HMPAO) single- photon-emission computed tomography (SPECT) in intractable temporal lobe epilepsy, and to determine why the technique may be misleading in the localization and lateralization of the seizure focus in some cases. Methods: Interictal 99Tcm HMPAO SPECT and proton magnetic resonance spectroscopy (1H MRS) of the mesial temporal regions were performed in 14 children with intractable temporal lobe epilepsy not caused by a foreign tissue lesion. Results: Hypoperfusion of one temporal lobe ipsilateral to the seizure focus was demonstrated in 10 (71%) of the child..