Journal article

EFFECTS OF VIGABATRIN ON PARTIAL SEIZURES AND COGNITIVE FUNCTION

RA GRUNEWALD, PJ THOMPSON, R CORCORAN, Z CORDEN, GD JACKSON, JS DUNCAN

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | B M J PUBLISHING GROUP | Published : 1994

Abstract

Forty five patients with refractory partial seizures were studied in a prospective, randomised, placebo controlled, add on, parallel group, double blind trial of the new antiepileptic drug vigabatrin (1.5 g twice daily) followed by open treatment. Seizure frequency was monitored throughout an eight week baseline, 20 weeks double blind, and up to 18 months of open vigabatrin treatment. Cognitive function, including measures of memory and concentration, mood, and behaviour were assessed at baseline and again during the 20th week of treatment. Vigabatrin was associated with a significant reduction in a measure of motor speed and overall score on a design learning test in the first 20 weeks of t..

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