Journal article
VITALITY trial: Protocol for a randomised controlled trial to establish the role of postnatal Vitamin D supplementation in infant immune health
KJ Allen, M Panjari, JJ Koplin, AL Ponsonby, P Vuillermin, LC Gurrin, R Greaves, N Carvalho, K Dalziel, MLK Tang, KJ Lee, M Wake, N Curtis, SC Dharmage
BMJ Open | Published : 2015
Abstract
Introduction: Postnatal vitamin D supplementation may be associated with a reduction in IgE-mediated food allergy, lower respiratory tract infections and improved bone health. Countries in the Northern hemisphere recommend universal infant vitamin D supplementation to optimise early vitamin D levels, despite the absence of large trials proving safety or efficacy for any disease outcome. With the aim of determining the clinical and cost-effectiveness of daily vitamin D supplementation in breastfed infants from age 6-8 weeks to 12 months of age, we have started a double-blind, randomised, placebo-controlled trial of daily 400 IU vitamin D supplementation during the first year of life, VITALITY..
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Funding Acknowledgements
This work was supported to date by The Isabel & John Gilbertson Charitable Trust and the Murdoch Children's Research Institute. KJA, MP, JJK, SCD, A-LP, LCG, MW all receive fellowship funding from the National Health and Medical Research Council (NHMRC) of Australia. NC receives funding from University of Melbourne, McKenzie Postdoctoral Fellowship.