Multivariate Clustering of Progression Profiles Reveals Different Depression Patterns in Prodromal Huntington Disease
Ji-in Kim, Jeffrey D Long, James A Mills, Elizabeth McCusker, Jane S Paulsen
NEUROPSYCHOLOGY | AMER PSYCHOLOGICAL ASSOC | Published : 2015
OBJECTIVE: Although Huntington disease (HD) is caused by an autosomal dominant mutation, its phenotypic presentation differs widely. Variability in clinical phenotypes of HD may reflect the existence of disease subtypes. This hypothesis was tested in prodromal participants from the longitudinal Neurobiological Predictors of Huntington Disease (PREDICT-HD) study. METHOD: We performed clustering using longitudinal data assessing motor, cognitive, and depression symptoms. Using data from 521 participants with 2,716 data points, we fit growth mixture models (GMM) that identify groups based on multivariate trajectories. RESULTS: In various GMM, different phases of disease progression were partiti..View full abstract
Awarded by National Institutes for Health, National Institute of Neurological Disorders and Stroke
Awarded by CHDI Foundation, Inc.
Awarded by Cognitive and Functional Brain Changes in Preclinical Huntington's Disease (HD)
Awarded by National Institutes of Health (NIH)
Awarded by Medical Research Council
Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
This research is supported by the National Institutes for Health, National Institute of Neurological Disorders and Stroke (Grant 5R01NS040068), CHDI Foundation, Inc. (Grants A3917 and 6266), Cognitive and Functional Brain Changes in Preclinical Huntington's Disease (HD; Grant 5R01NS054893).Jane S. Paulsen has received grant funding from the National Institutes of Health, CHDI Foundation, Inc., served on an advisory board for Lundbeck, LLC, and has a consulting agreement with ProPhase, LLC. Ji-in Kim, Jeffrey D. Long, James A. Mills, and Elizabeth McCusker have no competing interests to declare. We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington's Disease Society of America, and the Huntington Study Group. This publication was supported by the National Center for Advancing Translational Sciences, and the National Institutes of Health (NIH) through Grant 2 UL1 TR000442-06.