Journal article

ATTENUATION OF CHEMICALLY-INDUCED DEFENSE RESPONSE BY 5-HT(1) RECEPTOR AGONISTS ADMINISTERED INTO THE PERIAQUEDUCTAL GRAY

SRG BECKETT, AJ LAWRENCE, CA MARSDEN, PW MARSHALL

PSYCHOPHARMACOLOGY | SPRINGER VERLAG | Published : 1992

Abstract

The ability of 5-HT1 receptor agonists to modulate a chemically induced defence response has been studied in Lister hooded rats. Microinjections of the excitatory amino acid D,L-homocysteic acid (DLH) in both rostral and caudal dorsal periaqueductal gray matter (PAG) caused explosive motor behaviour characteristic of defence. This behaviour was quantified in terms of response duration, arena revolutions and number of defensive jumps. Direct administration into the PAG of either 5-carboxamidotryptamine (5-CT) or 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT) produced behaviours (decreased exploratory rearing, dose related onset of flat body posture) indicative of 5-HT1A receptor activatio..

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