Journal article

Increased anxiety 3 months after brief exposure to MDMA ('Ecstasy') in rats: Association with altered 5-HT transporter and receptor density

IS McGregor, KJ Clemens, G Van der Plasse, KM Li, GE Hunt, F Chen, AJ Lawrence

NEUROPSYCHOPHARMACOLOGY | NATURE PUBLISHING GROUP | Published : 2003

Abstract

Male Wistar rats were treated with 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") using either a high dose (4 x 5 mg/kg over 4 h) or low dose (1 x 5 mg/kg over 4 h) regimen on each of 2 consecutive days. After 10 weeks, rats were tested in the social interaction and emergence tests of anxiety. Rats previously given either of the MDMA dose regimens were significantly more anxious on both tests. After behavioral testing, and 3 months after the MDMA treatment, the rats were killed and their brains examined. Rats given the high-, but not the low-, dose MDMA treatment regimen exhibited significant loss of 5-hydroxytryptamine (5-HT) and 5-HIAA in the amygdala, hippocampus, striatum, and corte..

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