Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse
Bridgette D Semple, Linda J Noble-Haeusslein, Major Gooyit, Kayleen G Tercovich, Zhihong Peng, Trung T Nguyen, Valerie A Schroeder, Mark A Suckow, Mayland Chang, Jacob Raber, Alpa Trivedi
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
The gelatinases, matrix metalloproteinases (MMP)-2 and MMP-9, are thought to be key mediators of secondary damage in adult animal models of brain injury. Moreover, an acute increase in these proteases in plasma and brain extracellular fluid of adult patients with moderate-to-severe traumatic brain injuries (TBIs) is associated with poorer clinical outcomes and mortality. Nonetheless, their involvement after TBI in the pediatric brain remains understudied. Using a murine model of TBI at postnatal day 21 (p21), approximating a toddler-aged child, we saw upregulation of active and pro-MMP-9 and MMP-2 by gelatin zymography at 48 h post-injury. We therefore investigated the role of gelatinases on..View full abstract
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Awarded by National Institute of Neurological Disorders and Stroke
Awarded by Australian National Health and Medical Research Council
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
LJN received two grants from the National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov/) with grant numbers RO1NS077767 and RO1NS050159. BDS received a CJ Martin Early Career Fellowship from the Australian National Health and Medical Research Council with award number 1052505. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.