Journal article
The Haemonchus contortus kinome - A resource for fundamental molecular investigations and drug discovery
AJ Stroehlein, ND Young, PK Korhonen, A Jabbar, A Hofmann, PW Sternberg, RB Gasser
Parasites and Vectors | Published : 2015
Abstract
Background: Protein kinases regulate a plethora of essential signalling and other biological pathways in all eukaryotic organisms, but very little is known about them in most parasitic nematodes. Methods: Here, we defined, for the first time, the entire complement of protein kinases (kinome) encoded in the barber's pole worm (Haemonchus contortus) through an integrated analysis of transcriptomic and genomic datasets using an advanced bioinformatic workflow. Results: We identified, curated and classified 432 kinases representing ten groups, 103 distinct families and 98 subfamilies. A comparison of the kinomes of H. contortus and Caenorhabditis elegans (a related, free-living nematode) reveale..
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Funding Acknowledgements
Research funding from the National Health and Medical Research Council (NHMRC) and Australian Research Council (ARC) is gratefully acknowledged. Other support from the Australian Academy of Science, the Australian-American Fulbright Commission, Alexander von Humboldt Foundation, Melbourne Water Corporation as well as the Victorian Life Sciences Computation Initiative (VLSCI) and WormBase (www.wormbase.org) is gratefully acknowledged. PWS thanks the Howard Hughes Medical Institute (HHMI) and the National Institutes of Health (NIH). AJS is a recipient of a Melbourne International Research Scholarships (MIRS) and a Melbourne International Fee Remission Scholarship (MIFRS) from the University of Melbourne. NDY is an NHMRC Early Career Research (ECR) Fellow.