Journal article

NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation

Nicholas D Huntington, Hy Tabarias, Kirsten Fairfax, Jason Brady, Yoshihiro Hayakawa, Mariapia A Degli-Esposti, Mark J Smyth, David M Tarlinton, Stephen L Nutt

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2007

Abstract

NK cells are important for the clearance of tumors, parasites, and virus-infected cells. Thus, factors that control NK cell numbers and function are critical for the innate immune response. A subset of NK cells express the inhibitory killer cell lectin-like receptor G1 (KLRG1). In this study, we identify that KLRG1 expression is acquired during periods of NK cell division such as development and homeostatic proliferation. KLRG1(+) NK cells are mature in phenotype, and we show for the first time that these cells have a slower in vivo turnover rate, reduced proliferative response to IL-15, and poorer homeostatic expansion potential compared with mature NK cells lacking KLRG1. Transfer into lym..

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