Journal article

MICE LACKING THE C-REL PROTOONCOGENE EXHIBIT DEFECTS IN LYMPHOCYTE-PROLIFERATION, HUMORAL IMMUNITY, AND INTERLEUKIN-2 EXPRESSION

F KONTGEN, RJ GRUMONT, A STRASSER, D METCALF, RL LI, D TARLINTON, S GERONDAKIS

GENES & DEVELOPMENT | COLD SPRING HARBOR LAB PRESS | Published : 1995

Abstract

The c-rel proto-oncogene, which is expressed predominantly in hemopoietic cells encodes a subunit of the NF-kappa B-like family of transcription factors. In mice with an inactivated c-rel gene, whereas development of cells from all hemopoietic lineages appeared normal, humoral immunity was impaired and mature B and T cells were found to be unresponsive to most mitogenic stimuli. Phorbol ester and calcium ionophore costimulation, in contrast to certain membrane receptor-mediated signals, overcame the T cell-proliferative defect, demonstrating that T cell proliferation occurs by Rel-dependent and -independent mechanisms. The ability of exogenous interleukin-2 to restore T Cell, but not B cell,..

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University of Melbourne Researchers