Decreased Bone Formation and Osteopenia in Lamin A/C-Deficient Mice
Wei Li, Li Sze Yeo, Christopher Vidal, Thomas McCorquodale, Markus Herrmann, Diane Fatkin, Gustavo Duque
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2011
Age-related bone loss is associated with changes in bone cellularity with characteristically low levels of osteoblastogenesis. The mechanisms that explain these changes remain unclear. Although recent in vitro evidence has suggested a new role for proteins of the nuclear envelope in osteoblastogenesis, the role of these proteins in bone cells differentiation and bone metabolism in vivo remains unknown. In this study, we used the lamin A/C null (Lmna⁻/⁻) mice to identify the role of lamin A/C in bone turnover and bone structure in vivo. At three weeks of age, histological and micro computed tomography measurements of femurs in Lmna⁻/⁻ mice revealed a significant decrease in bone mass and micr..View full abstract
Awarded by Australian National Health and Medical Research Council
This work was supported by operating grants from the Australian National Health and Medical Research Council (Grant 632766 for GD and grants 213401, 354400, 404808 for DF), and the Nepean Hospital Medical Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.