Polyalanine expansions drive a shift into alpha-helical clusters without amyloid-fibril formation
Saskia Polling, Angelique R Ormsby, Rebecca J Wood, Kristie Lee, Cheryl Shoubridge, James N Hughes, Paul Q Thomas, Michael DW Griffin, Andrew F Hill, Quill Bowden, Till Boecking, Danny M Hatters
Nature Structural & Molecular Biology | NATURE PUBLISHING GROUP | Published : 2015
Related Projects (3)
Awarded by Australian Research Council
Awarded by Australian National Health and Medical Research Council
This work was funded by the Australian Research Council (Discovery Project Grant DP120102763 (D.M.H.) and Future Fellowships FT120100039 (D.M.H.), FT100100411 (T.B.) and FT100100560 (A.F.H.)) and by the Australian National Health and Medical Research Council (Project Grants APP1049458 (D.M.H.), 628946 (A.F.H.), 465401 (P.Q.T.) and APP1049459 (D.M.H. and T.B.)). The GFP-NLS vector was kindly provided by G. Mosely (University of Melbourne).