Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration

Robert P Finger; Elaine Chong; Myra B McGuinness; Luba D Robman; Khin Zaw Aung; Graham Giles; Paul N Baird; Robyn H Guymer

Journal article

Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration

Robert P Finger, Elaine Chong, Myra B McGuinness, Luba D Robman, Khin Zaw Aung, Graham Giles, Paul N Baird, Robyn H Guymer

OPHTHALMOLOGY | ELSEVIER SCIENCE INC | Published : 2016

DOI: 10.1016/j.ophtha.2015.10.029

Abstract

PURPOSE: To determine the prevalence of reticular pseudodrusen (RPD) and its association with age-related macular degeneration (AMD) and AMD risk factors in a large sample. DESIGN: Community-based cohort study in Melbourne, Victoria, Australia. PARTICIPANTS: A total of 21,130 participants 48 to 86 years of age available for ophthalmic assessment at follow-up from 2003 through 2007. METHODS: Lifestyle, diet, and anthropometric measurements were obtained at baseline and follow-up. At follow-up, digital macular color photographs were graded for early, intermediate, and late AMD as well as the presence of RPD. Data were analyzed using multinomial logistic regression controlling for age, gender, ..

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University of Melbourne Researchers

Graham Giles Author Melbourne School of Population and Global Health

Myra McGuinness Author Melbourne School of Population and Global Health

Paul Baird Author Ophthalmology Eye and Ear Hospital

Robyn Guymer Author Ophthalmology Eye and Ear Hospital

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Grants

Awarded by National Health & Medical Research Council of Australia

Awarded by American Health Assistance Foundation

Awarded by National Health & Medical Research Council of Australia Centre of Research Excellence

Funding Acknowledgements

Supported by the National Health & Medical Research Council of Australia (program grant no.: 209057, capacity building grant no.: 251533, and enabling grant no.: 396414); VicHealth and Cancer Council Victoria (cohort recruitment); Ophthalmic Research Institute of Australia; American Health Assistance Foundation (grant no.: M2008-082); Jack Brockhoff Foundation; John Reid Charitable Trust; Perpetual Trustees; the Charles Viertel Charitable Foundation; the Lloyd and Kathleen Ansell Ophthalmology Foundation; and the Mankiewicz-Zelkin Fellowship of the University of Melbourne, Melbourne, Australis (R.P.F.); the Victorian Centre for Biostatistics (Australian Postgraduate Award and studentship funded by National Health & Medical Research Council of Australia Centre of Research Excellence grant no.: 1035261 [M.B.M.]). The Centre for Eye Research Australia is supported by the National Health & Medical Research Council of Australia (Centre of Clinical Research Excellence grant no.: 529923) and the Victorian Government (operational infrastructure support). All sponsors are located in Australia except the American Health Assistance Foundation which is located in the United States. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.