Methylprednisolone Does Not Reduce Persistent Pain after Cardiac Surgery
Alparslan Turan, Emilie P Belley-Cote, Jessica Vincent, Daniel I Sessler, Philip J Devereaux, Salim Yusuf, Rachel van Oostveen, Gustavo Cordova, Jean-Pierre Yared, Hai Yu, Jean-Francois Legare, Alistair Royse, Antoine Rochon, Vivian Nasr, Sabry Ayad, Mackenzie Quantz, Andre Lamy, Richard P Whitlock
Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
BACKGROUND: Persistent incisional pain is common after cardiac surgery and is believed to be in part related to inflammation and poorly controlled acute pain. Methylprednisolone is a corticosteroid with substantial antiinflammatory and analgesic properties and is thus likely to ameliorate persistent surgical pain. Therefore, the authors tested the primary hypothesis that patients randomized to methylprednisolone have less persistent incisional pain than those given placebo. METHODS: One thousand forty-three patients having cardiopulmonary bypass for cardiac surgery via a median sternotomy were included in this substudy of Steroids in Cardiac Surgery (SIRS) trial. Patients were randomized to ..View full abstract
Supported by the Canadian Institutes of Health Research, Ottawa, Ontario, Canada. The sponsor was not involved in study design, data analysis, or manuscript preparation. None of the authors has a personal financial interest related to this research.