Journal article
SNPs and breast cancer risk prediction for African American and Hispanic women
R Allman, GS Dite, JL Hopper, O Gordon, A Starlard-Davenport, R Chlebowski, C Kooperberg
Breast Cancer Research and Treatment | Published : 2015
Abstract
For African American or Hispanic women, the extent to which clinical breast cancer risk prediction models are improved by including information on susceptibility single nucleotide polymorphisms (SNPs) is unknown, even though these women comprise increasing proportions of the US population and represent a large proportion of the world’s population. We studied 7539 African American and 3363 Hispanic women from the Women’s Health Initiative. The age-adjusted 5-year risks from the BCRAT and IBIS risk prediction models were measured and combined with a risk score based on >70 independent susceptibility SNPs. Logistic regression, adjusting for age group, was used to estimate risk associations with..
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Awarded by National Institutes of Health
Funding Acknowledgements
The authors thank Chancellor Hohensee of the Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington for assistance in compiling the dataset and Dr Adrian Bickerstaffe of the Centre for Epidemiology and Biostatistics, The University of Melbourne, Australia for assistance in batch processing the IBIS data. The WHI program is funded by the National Heart, Lung, and Blood Institute, NIH, U.S. Department of Health and Human Services through contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119,32122, 42107-26, 42129-32, and 44221.