Journal article
Olanzapine or chlorpromazine plus lithium in first episode psychotic mania: An 8-week randomised controlled trial
P Conus, M Berk, SM Cotton, L Kader, C Macneil, MK Hasty, K Hallam, M Lambert, BP Murphy, PD McGorry
European Psychiatry | Published : 2015
Abstract
Background: Treatment strategies for mental disorders may vary according to illness stage. However no data currently exist to guide treatment in first episode psychotic mania. The aim of this study was to compare the safety and efficacy profile of chlorpromazine and olanzapine, as add-on to lithium, in patients with a first episode of psychotic mania, expecting better safety profile and adherence to olanzapine but similar efficacy for both treatments. Methods: Data from 83 patients were collected in an 8-week randomised controlled trial on clinical variables, side effects, vital signs, and weight. Analyses of treatment differences over time were based on intent-to-treat principles. Kaplan-Me..
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Funding Acknowledgements
This study was supported by an investigator initiated trial grant from Eli Lilly Australia. However, this company had no influence on the study design and was not involved in any way in data collection, data analysis and interpretation of the results. Dr Philippe Conus is supported by a grant from the Leenaards Foundation, Switzerland. Dr Sue Cotton is supported by the Ronald Phillip Griffith Fellowship from Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne.