Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

FR Day; KS Ruth; DJ Thompson; KL Lunetta; N Pervjakova; DI Chasman; L Stolk; HK Finucane; P Sulem; B Bulik-Sullivan; T Esko; AD Johnson; CE Elks; N Franceschini; C He; E Altmaier; JA Brody; LL Franke; JE Huffman; MF Keller; PF McArdle; T Nutile; E Porcu; A Robino; LM Rose; UM Schick; JA Smith; A Teumer; M Traglia; D Vuckovic; J Yao; W Zhao; E Albrecht; N Amin; T Corre; JJ Hottenga; M Mangino; AV Smith; T Tanaka; GR Abecasis; IL Andrulis; H Anton-Culver; AC Antoniou; V Arndt; AM Arnold; C Barbieri; MW Beckmann; A Beeghly-Fadiel; J Benitez; L Bernstein; SJ Bielinski; C Blomqvist; E Boerwinkle; NV Bogdanova; SE Bojesen; MK Bolla; AL Borresen-Dale; TS Boutin; H Brauch; H Brenner; T Brüning; B Burwinkel; A Campbell; H Campbell; SJ Chanock; JR Chapman; YD Ida Chen; G Chenevix-Trench; FJ Couch; AD Coviello; A Cox; K Czene; H Darabi; I De Vivo; EW Demerath; J Dennis; P Devilee; T Dörk; I Dos-Santos-Silva; AM Dunning; JD Eicher; PA Fasching; JD Faul; J Figueroa; D Flesch-Janys; I Gandin; ME Garcia; M Garciá-Closas; GG Giles; GG Girotto; MS Goldberg; A González-Neira; MO Goodarzi; ML Grove; DF Gudbjartsson; P Guénel; X Guo; CA Haiman; P Hall; U Hamann

Journal article

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

FR Day, KS Ruth, DJ Thompson, KL Lunetta, N Pervjakova, DI Chasman, L Stolk, HK Finucane, P Sulem, B Bulik-Sullivan, T Esko, AD Johnson, CE Elks, N Franceschini, C He, E Altmaier, JA Brody, LL Franke, JE Huffman, MF Keller Show all

Obstetrical and Gynecological Survey | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

DOI: 10.1097/01.ogx.0000473766.71624.99

Abstract

ABSTRACT Menopause timing has a major impact on infertility and risk of disease. Younger age at natural (nonsurgical) menopause (ANM) is associated with a higher risk of osteoporosis, cardiovascular disease, and type 2 diabetes and a lower risk of breast cancer. Late menopause is associated with a higher risk of breast cancer. It is well known that the age at which women go through menopause is partly determined by genes, but the underlying mechanisms are poorly understood. Genome-wide association studies have identified 18 common genetic variants associated with ANM. These variants explain less than 5% of the variation in ANM compared with the 21% explained by all common variants on genome-..

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