Cooperative international neuromuscular research group duchenne natural history study demonstrates insufficient diagnosis and treatment of cardiomyopathy in duchenne muscular dystrophy

C Spurney; R Shimizu; LP Morgenroth; H Kolski; H Gordish-Dressman; PR Clemens; M Cregan; E Goude; M Glick; L Johnson; J Han; N Joyce; D Kilmer; A Nicorici; C Chidambaranathan; S Kumar; L Eliasoph; E Hosaki; A Gonzales; V Harris; A Chiu; J Thannhauser; L Walker; C Wright; M Yousefi; AC Alhander; L Wahlgren; AB Ekstrom; AK Kroksmark; U Sterky; M Birkmeier; T Duong; S Kaminski; K Carroll; K DeValle; R Kennedy; A Kornberg; V Rodriguez; D Villano; AB Leve; E Wisband; D Yaffe; L Andreone; J Corderi; L Mesa; L Levi; K Coleman-Wood; A Hoffman; W Korn-Petersen; N Kuntz; D Selcen; H Abdel-Hamid; C Bise; A Craig; C Nguyen; J Weimer; M Al-Lozi; J Florence; P Golumbak; G Lopate; J Malane; B Malkus; R Renna; J Schierbacker; C Seiner; C Wulf; S Blair; B Grillo; K Jones; E Monasterio; M Barrett-Adair; J Clift; C Feliciano; R Young; K Rose; R Webster; S Wicks; L Chen; C Kennedy; B Deliz; S Espada; P Fuste; C Luciano; M Beneggi; L Capone; A Molteni; V Morettini; A Gupta; R McNeil; A Erickson; M Margolis; C Naughton; G Parry; D Walk; A Arrieta; N Bartley; P Canelos; R Casper; A Cnaan

Journal article

Cooperative international neuromuscular research group duchenne natural history study demonstrates insufficient diagnosis and treatment of cardiomyopathy in duchenne muscular dystrophy

C Spurney, R Shimizu, LP Morgenroth, H Kolski, H Gordish-Dressman, PR Clemens, M Cregan, E Goude, M Glick, L Johnson, J Han, N Joyce, D Kilmer, A Nicorici, C Chidambaranathan, S Kumar, L Eliasoph, E Hosaki, A Gonzales, V Harris Show all

Muscle and Nerve | Published : 2014

DOI: 10.1002/mus.24163

Abstract

Introduction: Cardiomyopathy is a common cause of morbidity and death in patients with Duchenne muscular dystrophy (DMD). Methods: This investigation was a cross-sectional cross-sectional analysis of clinical data from the multi-institutional Cooperative International Neuromuscular Research Group (CINRG) DMD Natural History Study of 340 DMD patients aged 2-28 years. Cardiomyopathy was defined as shortening fraction (SF) <28% or ejection fraction (EF) 0.68). In patients with cardiomyopathy, 57% (27 of 47) reported not taking any cardiac medications. Cardiac medications were used in 12% (15 of 127) of patients without cardiomyopathy. Conclusions: We found that echocardiograms were underutilize..

View full abstract

University of Melbourne Researchers

Rachel Kennedy Author

Andrew Kornberg Author

Grants

Awarded by National Center for Research Resources

Funding Acknowledgements

This project was funded through grants from the U.S. Department of Education/NIDRR (#H133B031118, #H133B090001), the NIH/NINDS Paul D. Wellstone Muscular Dystrophy Research Centers (U54HD053177), the U.S. Department of Defense (#W81XWH-09-1-0592) and NIH/NCRR (#UL1RR031988).