Journal article

Childhood chronic inflammatory demyelinating polyneuropathy: clinical course and long-term outcome

MM Ryan, PJ Grattan-Smith, PG Procopis, G Morgan, RA Ouvrier

Neuromuscular Disorders | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2000


We reviewed the clinical history, electrophysiologic and pathologic findings, and response to therapy of 16 children with chronic inflammatory demyelinating polyneuropathy. The majority presented with lower limb weakness. Sensory loss was uncommon. The illness was monophasic in seven children, relapsing in six, and three had a slowly progressive course. All patients were treated with immunosuppressive agents. In 11, the initial treatment was prednisolone. All had at least a short-term response but five went on to develop a relapsing course. Intravenous immunoglobulin was the initial treatment in four patients. Three responded rapidly, with treatment being stopped after a maximum of 5 months...

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