Journal article
The PneuCarriage Project: A Multi-Centre Comparative Study to Identify the Best Serotyping Methods for Examining Pneumococcal Carriage in Vaccine Evaluation Studies
C Satzke, EM Dunne, BD Porter, KP Klugman, EK Mulholland, JE Vidal, F Sakai, JE Strachan, DC Hay Burgess, D Holtzman, K Boelsen, M Habib, J Manning, BD Ortika, CL Pell, JA Smyth, M Antonio, KL O’Brien, RM Robins-Browne, J Anthony Scott Show all
Plos Medicine | PUBLIC LIBRARY SCIENCE | Published : 2015
Open access
Abstract
Background: The pneumococcus is a diverse pathogen whose primary niche is the nasopharynx. Over 90 different serotypes exist, and nasopharyngeal carriage of multiple serotypes is common. Understanding pneumococcal carriage is essential for evaluating the impact of pneumococcal vaccines. Traditional serotyping methods are cumbersome and insufficient for detecting multiple serotype carriage, and there are few data comparing the new methods that have been developed over the past decade. We established the PneuCarriage project, a large, international multi-centre study dedicated to the identification of the best pneumococcal serotyping methods for carriage studies. Methods and Findings: Referenc..
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Funding Acknowledgements
This project was initially funded through the PneumoCarr Consortium (Grant 37875 funded by the Grand Challenges in Global Health Initiative which was supported by The Bill & Melinda Gates Foundation, the Foundation for the National Institutes of Health, the Wellcome Trust, and the Canadian Institutes of Health Research). The PneuCarriage project was subsequently directly funded by The Bill & Melinda Gates Foundation (www.gatesfoundation.org), Grant 52099. This project was also supported by the Murdoch Childrens Research Institute (www.mcri.edu.au) and the Victorian Government's Operational Infrastructure Support Program. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript; except for the specific roles of DCHB, DH and KPK as described in the author contributions. All authors have read, and confirm that they meet, ICMJE criteria for authorship.