Journal article
Is carbamazepine a human teratogen?
FJE Vajda, TJ O'Brien, J Graham, CM Lander, MJ Eadie
Journal of Clinical Neuroscience | Published : 2016
Abstract
The foetal outcomes of 2,635 pregnancies recorded in the Australian Pregnancy Register were studied. In at least the initial 4 months of 515 pregnancies, there had been no intrauterine exposure to antiepileptic drugs, though the women involved in 264 of these pregnancies took antiepileptic drugs in later pregnancies. Compared with these 515 drug-unexposed pregnancies, foetal malformations risks were increased more than five-fold in association with valproate monotherapy, and more than doubled in association with carbamazepine monotherapy (p < 0.05). There were no statistically significant increases in malformation rates associated with other more commonly used antiepileptic drugs, while the ..
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Funding Acknowledgements
We gratefully acknowledge the help provided by professional and lay colleagues in referring patients to the Australian Pregnancy Register, and also thank the Scientific Advisory Board and the Ethical Research Committees of St. Vincent's Hospital, Monash Medical Centre, the Royal Melbourne Hospital and other institutions for their continuing ethics oversight of its activities. The Epilepsy Society of Australia, The Royal Melbourne Hospital Neuroscience Foundation, Epilepsy Australia and NHMRC and the pharmaceutical companies Sanofi-Aventis, UCB Pharma, Janssen-Cilag, Novartis, Sci-Gen, Eisai and Genzyme have provided financial assistance that has helped the Register maintain its activities over the years.