Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein

Julien Tailhades; Ashish Sethi; Emma J Petrie; Paul R Gooley; Ross A Bathgate; John D Wade; Mohammed A Hossain

Journal article

Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein

Julien Tailhades, Ashish Sethi, Emma J Petrie, Paul R Gooley, Ross A Bathgate, John D Wade, Mohammed A Hossain

Chemistry - A European Journal | WILEY-V C H VERLAG GMBH | Published : 2016

DOI: 10.1002/chem.201503599

University of Melbourne Researchers

Paul Gooley Author Biochemistry and Pharmacology

Ashish Sethi Author Biochemistry and Pharmacology

Akhter Hossain Author Florey Department of Neuroscience and Mental Health

Emma Petrie Author Medicine, Dentistry and Health Sciences

Ross Bathgate Author Florey Department of Neuroscience and Mental Health

Related Projects (6)

Functional analysis of relaxin and INSL3 receptors

The peptide hormone relaxin is currently in clinical trials to treat acute heart failure. The related hormone INSL3 has important roles in f..

Enhancing the clinical potential of relaxin

The hormone relaxin mediates cardiovascular and kidney changes during pregnancy. These important functions have led to its current use in cl..

Determining modes of binding and activation of complex G-protein coupled receptor targets

The peptide hormones relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as..

Structure-function relationship of human relaxins.

Relaxin is a peptide that is involved in the regulation of the birth process. It has considerable promise as an anti-fibrotic agent. Recentl..

Functional analysis of relaxin and INSL3 receptors

The peptide hormone relaxin is currently in clinical trials to treat acute heart failure. The related hormone INSL3 has important roles in f..

RESEARCH FELLOWSHIP

Relaxin family peptides are small proteins that have numerous essential biological roles in the vascular system, brain and gut. The hormone ..

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This research was partially funded by National Health and Medical Research Council (NHMRC) of Australia Project Grants 508995 and 1023078 (J.D.W., M.A.H., R.A.D.B.) and grants 628427 and 1043750 (R.A.D.B., P.R.G.). M.A.H. was the recipient of a Florey Foundation Fellowship, R.A.D.B. is a NHMRC Senior Research Fellow (APP1042650) and J.D.W. is an NHMRC Principal Research Fellow (APP5018148). Research at The Florey Institute of Neuroscience and Mental Health is supported by the Victorian Government Operational Infrastructure Program.