Association of sex hormone-binding globulin and free testosterone with mortality in men with type 2 diabetes mellitus
Aye N Tint, Rudolf Hoermann, Henry Wong, Elif I Ekinci, Richard J MacIsaac, George Jerums, Jeffrey D Zajac, Mathis Grossmann
EUROPEAN JOURNAL OF ENDOCRINOLOGY | BIOSCIENTIFICA LTD | Published : 2016
OBJECTIVE: Low circulating testosterone levels have been associated with increased mortality in men. We hypothesized that the prognostic role of testosterone in men with type 2 diabetes mellitus (T2DM) is influenced by its carrier protein sex hormone-binding globulin (SHBG). DESIGN: We conducted a prospective cohort study at a tertiary referral centre. METHODS: In total, 531 men with T2DM presenting to a diabetes clinic in 2004-2005 were followed prospectively until death, or July 31, 2014, and a survival analysis was performed. The main outcome measure was all cause mortality. RESULTS: Over a mean (S.D.) follow up of 7.6 years (2.6) 175 men (33%) died. In Cox proportional hazard models both..View full abstract
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Awarded by National Health and Medical Research Council of Australia Career Development Fellowship
M Grossmann was supported by a National Health and Medical Research Council of Australia Career Development Fellowship (# 1024139).