Journal article
The effect of methadone on emotional reactivity
SM Savvas, AA Somogyi, JM White
Addiction | WILEY-BLACKWELL | Published : 2012
Abstract
Aims Opioids have been implicated in emotion regulation. Opioid users report decreased negative emotional response, but there has been no formal study on the effect of opioid administration on emotional reactivity. The aim of this study was to investigate the effect of methadone on emotional reactivity in methadone-maintained patients. Design Velten's mood induction procedures were used to induce elative and depressive emotional reactions in the subjects. Each group was administered both induction procedures at 0 hour and 3 hours (corresponding with trough and peak plasma methadone concentrations in methadone subjects). Setting A drug treatment clinic with an out-patient methadone maintenanc..
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Funding Acknowledgements
The authors would like to thank the staff at Warinilla Clinic, SA, Australia, for their generous assistance. We would also like to thank the staff at Midnight Pharmacy and Brad Jackson Pharmacy, SA, Australia, for their assistance with recruitment. This study was supported through a National Health and Medical Research Council Project Grant.