Journal article
Estimating the Future Impact of a Multi-Pronged Intervention Strategy on Ocular Disease Sequelae Caused by Trachoma: A Modeling Study
M Gambhir, NC Grassly, MJ Burton, AW Solomon, HR Taylor, DC Mabey, IM Blake, MG Basáñez
Ophthalmic Epidemiology | Published : 2015
Open access
Abstract
Purpose: Trachoma control programs are underway in endemic regions worldwide. They are based on the SAFE strategy (Surgery for trichiasis, Antibiotic distribution, Facial cleanliness, and Environmental improvement). Although much is known about the effect of community-wide treatment with antibiotics on the prevalence of Chlamydia trachomatis, the impact of the SAFE strategy on severe ocular disease sequelae (the main focus of the Global Elimination of blinding Trachoma by 2020 program) remains largely unknown.Methods: We use a mathematical model to explore the impact of each of the components of the SAFE strategy, individually and together, on disease sequelae, arising from repeat infection ..
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Awarded by Medical Research Council
Funding Acknowledgements
The International Trachoma Initiative (ITI) financed the initial development of the trachoma models presented here. NCG acknowledges the Royal Society for a University Research Fellowship, and the Medical Research Council, UK, for Centre funding support. MJB thanks the Wellcome Trust for a fellowship [Grant No: 098481/Z/12/Z]. M-GB thanks the Wellcome Trust and the Royal Society for project grants in neglected tropical diseases. The field studies used to develop the model were supported by a Wellcome Trust-Burroughs Wellcome Fund grant to DCM and RLB [Grant No. 052134]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.