The effect of iodine supplementation in pregnancy on early childhood neurodevelopment and clinical outcomes: Results of an aborted randomised placebo-controlled trial

Abstract

Background: Concern that mild iodine deficiency in pregnancy may adversely affect neurodevelopment of offspring has led to recommendations for iodine supplementation in the absence of evidence from randomised controlled trials. The primary objective of the study was to investigate the effect of iodine supplementation during pregnancy on childhood neurodevelopment. Secondary outcomes included pregnancy outcomes, maternal thyroid function and general health. Methods: Women with a singleton pregnancy of fewer than 20weeks were randomly assigned to iodine (150μg/d) or placebo from trial entry to birth. Childhood neurodevelopment was assessed at 18months by using Bayley Scales of Infant and Toddl..