Journal article

Declining transition rates to psychotic disorder in "ultra-high risk" clients: Investigation of a dilution effect

Jessica A Hartmann, Hok Pan Yuen, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Stephen J Wood, Suzie Lavoie, Barnaby Nelson

SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2016

Abstract

During recent years, a decrease has been noted in the rate of transition of ultra-high risk (UHR) clients to a psychotic disorder. Although important to the concept of the at-risk mental state, the reasons for this decline remain largely unknown. We investigated the possibility of a 'dilution effect' in contributing to the decline, i.e. if later UHR cohorts present with less severe clinical intake characteristics than earlier cohorts. Firstly, clinical intake characteristics of a large UHR sample (n=397) were compared across baseline year epochs (1995-2006). Characteristics showing significant differences were included in a Cox-regression to examine if they could explain the decline in trans..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Program


Awarded by Rubicon Fellowship from the Netherlands Organisation for Scientific Research


Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Clinical Career Developmental Award


Awarded by NHMRC Senior Research Fellowship


Awarded by NHMRC Early Career Fellowship


Awarded by Medical Research Council


Funding Acknowledgements

We acknowledge the funding support of National Health and Medical Research Council (NHMRC) Program grants 350241 and 566529 (awarded to PMc, ARY and SJW) and the Colonial Foundation. JAH was supported by a Rubicon Fellowship from the Netherlands Organisation for Scientific Research (NWO 825.15.015), BN was supported by an NHMRC Career Development Fellowship (1027532), SJW was supported by an NHMRC Clinical Career Developmental Award (359223), and ARY was supported by an NHMRC Senior Research Fellowship (566593). AL is supported by a NHMRC Early Career Fellowship (1072593).