Declining transition rates to psychotic disorder in "ultra-high risk" clients: Investigation of a dilution effect

JA Hartmann; HP Yuen; PD McGorry; AR Yung; A Lin; SJ Wood; S Lavoie; B Nelson

Journal article

Declining transition rates to psychotic disorder in "ultra-high risk" clients: Investigation of a dilution effect

JA Hartmann, HP Yuen, PD McGorry, AR Yung, A Lin, SJ Wood, S Lavoie, B Nelson

Schizophrenia Research | ELSEVIER | Published : 2016

DOI: 10.1016/j.schres.2015.11.026

Abstract

During recent years, a decrease has been noted in the rate of transition of ultra-high risk (UHR) clients to a psychotic disorder. Although important to the concept of the at-risk mental state, the reasons for this decline remain largely unknown. We investigated the possibility of a 'dilution effect' in contributing to the decline, i.e. if later UHR cohorts present with less severe clinical intake characteristics than earlier cohorts.Firstly, clinical intake characteristics of a large UHR sample (n = 397) were compared across baseline year epochs (1995-2006). Characteristics showing significant differences were included in a Cox-regression to examine if they could explain the decline in tran..

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University of Melbourne Researchers

Hok Yuen Author

Patrick McGorry Author

Stephen Wood Author

Suzie Lavoie Author

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Grants

Awarded by Medical Research Council

Funding Acknowledgements

We acknowledge the funding support of National Health and Medical Research Council (NHMRC) Program grants 350241 and 566529 (awarded to PMc, ARY and SJW) and the Colonial Foundation. JAH was supported by a Rubicon Fellowship from the Netherlands Organisation for Scientific Research (NWO 825.15.015), BN was supported by an NHMRC Career Development Fellowship (1027532), SJW was supported by an NHMRC Clinical Career Developmental Award (359223), and ARY was supported by an NHMRC Senior Research Fellowship (566593). AL is supported by a NHMRC Early Career Fellowship (1072593).