Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice

AA Rasmiena; CK Barlow; N Stefanovic; K Huynh; R Tan; A Sharma; D Tull; JB de Haan; PJ Meikle

Journal article

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice

AA Rasmiena, CK Barlow, N Stefanovic, K Huynh, R Tan, A Sharma, D Tull, JB de Haan, PJ Meikle

Atherosclerosis | Published : 2015

DOI: 10.1016/j.atherosclerosis.2015.10.096

Abstract

Background and aim: We previously reported a negative association of circulating plasmalogens (phospholipids with proposed atheroprotective properties) with coronary artery disease. Plasmalogen modulation was previously demonstrated in animals but its effect on atherosclerosis was unknown. We assessed the effect of plasmalogen enrichment on atherosclerosis of murine models with differing levels of oxidative stress. Methods and results: Six-week old ApoE- and ApoE/glutathione peroxidase-1 (GPx1)-deficient mice were fed a high-fat diet with/without 2% batyl alcohol (precursor to plasmalogen synthesis) for 12 weeks. Mass spectrometry analysis of lipids showed that batyl alcohol supplementation ..

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University of Melbourne Researchers

Peter Meikle Author

Grants

Funding Acknowledgements

This work was supported by a Melbourne International Research Scholarship from the University of Melbourne, Australia awarded to AAR, a National Health and Medical Research Council of Australia Senior Research Fellowship awarded to PJM and the OIS Program of the Victorian Government, Australia.