Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

Sidonia BG Eckle; Alexandra J Corbett; Andrew N Keller; Zhenjun Chen; Dale I Godfrey; Ligong Liu; Jeffrey YW Mak; David P Fairlie; Jamie Rossjohn; James McCluskey

Journal article

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

Sidonia BG Eckle, Alexandra J Corbett, Andrew N Keller, Zhenjun Chen, Dale I Godfrey, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Jamie Rossjohn, James McCluskey

JOURNAL OF BIOLOGICAL CHEMISTRY | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2015

DOI: 10.1074/jbc.R115.685990

Abstract

Vitamin B2 (riboflavin) is essential for metabolic functions and is synthesized by many bacteria, yeast, and plants, but not by mammals and other animals, which must acquire it from the diet. In mammals, modified pyrimidine intermediates from the microbial biosynthesis of riboflavin are recognized as signature biomarkers of microbial infection. This recognition occurs by specialized lymphocytes known as mucosal associated invariant T (MAIT) cells. The major histocompatibility class I-like antigen-presenting molecule, MR1, captures these pyrimidine intermediates, but only after their condensation with small molecules derived from glycolysis and other metabolic pathways to form short-lived ant..

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University of Melbourne Researchers

Dale Godfrey Author Microbiology and Immunology

Alexandra Corbett Author Microbiology and Immunology

James McCluskey Author

Sidonia Eckle Author Microbiology and Immunology

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Grants

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by Australia Fellowship

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

[ "This work was supported by Australian Research Council Grants E140100011 and LE110100106 and National Health and Medical Research Council (NHMRC) of Australia Grants 1016629, 1013667, 1062889, and 1063587. The authors declare that they have no conflicts of interest with the contents of this article.", "Supported by an Early Career Researcher award from The University of Melbourne.", "Recipient of Australia Fellowship AF50. To whom correspondence may be addressed. E-mail: jamie.rossjohn@monash.edu." ]