Conservative oxygen therapy in mechanically ventilated patients following cardiac arrest: A retrospective nested cohort study
Glenn M Eastwood, Aiko Tanaka, Emilo Daniel Valenzuela Espinoza, Leah Peck, Helen Young, Johan Martensson, Ling Zhang, Neil J Glassford, Yu-Feng Frank Hsiao, Satoshi Suzuki, Rinaldo Bellomo
RESUSCITATION | ELSEVIER IRELAND LTD | Published : 2016
BACKGROUND: In mechanically ventilated (MV) cardiac arrest (CA) survivors admitted to the intensive care unit (ICU) avoidance of hypoxia is considered crucial. However, avoidance of hyperoxia may also be important. A conservative approach to oxygen therapy may reduce exposure to both. METHODS: We evaluated the introduction of conservative oxygen therapy (target SpO2 88-92% using the lowest FiO2) during MV for resuscitated CA patients admitted to the ICU. RESULTS: We studied 912 arterial blood gas (ABG) datasets: 448 ABGs from 50 'conventional' and 464 ABGs from 50 'conservative' oxygen therapy patients. Compared to the conventional group, conservative group patients had significantly lower P..View full abstract
Anaesthesia Intensive Care Trust Fund, Austin Hospital, Heidelberg, Victoria, Australia.