Synthetic approaches to the alkaloids of the ancistrocladaceae: (-)-O-methylancistrocladine and ( )-O-methylhamatine

Abstract

An asymmetric total synthesis of the naphthylisoquinoline alkaloid (-)-O-methylancistrocladine (2) is described; the synthetic method also provides routes to the atropisomer O-methylhamatine (4) and the enantiomers of these alkaloids.