Journal article

Seminal Plasma Anti-HIV Antibodies Trigger Antibody-dependent Cellular Cytotoxicity: Implications for HIV Transmission

Matthew S Parsons, Vijaya Madhavi, Fernanda Ana-Sosa-Batiz, Rob J Center, Kim M Wilson, Torsak Bunupuradah, Kiat Ruxrungtham, Stephen J Kent

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

Abstract

Recent evidence from HIV vaccine trials in humans and non-human primates suggests that nonneutralizing antibody functions, such as antibody-dependent cellular cytotoxicity (ADCC), are an important component of vaccine-mediated protection. Whether anti-HIV ADCC antibodies are present in seminal fluid, however, is not known. We assessed whether anti-HIV antibodies within seminal plasma mediate ADCC and activate natural killer (NK) cells. Using matched blood and seminal plasma samples, we detected anti-HIV IgG within samples from all 11 HIV-infected donors. Furthermore, anti-HIV antibodies within the seminal plasma triggered detectable ADCC in 9 of 11 donors and activated NK cells in 6 of 11 do..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Thai National Health Security Office


Funding Acknowledgements

Supported by program Grant no. 1052979 from the National Health and Medical Research Council (NHMRC). HIV STAR (The HIV Second-line Therapy AntiRetroviral study in patients who failed NNRTI-based regimens; clinicaltrial.gov number: NCT00627055) was supported by grants from the Thai National Health Security Office, Swiss cohort study, and the National Research Council of Thailand. M.S.P. is the recipient of a Canadian Institutes of Health Research (CIHR) postdoctoral fellowship. K.R. is a Senior Research Scholar, supported by the Thailand Research Fund (TRF).