A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study
R Daglas, SM Cotton, K Allott, M Yuecel, CA Macneil, MK Hasty, B Murphy, C Pantelis, KT Hallam, LP Henry, P Conus, A Ratheesh, L Kader, M Th Wong, PD McGorry, M Berk
EUROPEAN PSYCHIATRY | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2016
BACKGROUND: Cognitive deficits have been reported during the early stages of bipolar disorder; however, the role of medication on such deficits remains unclear. The aim of this study was to compare the effects of lithium and quetiapine monotherapy on cognitive performance in people following first episode mania. METHODS: The design was a single-blind, randomised controlled trial on a cohort of 61 participants following first episode mania. Participants received either lithium or quetiapine monotherapy as maintenance treatment over a 12-month follow-up period. The groups were compared on performance outcomes using an extensive cognitive assessment battery conducted at baseline, month 3 and mo..View full abstract
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Awarded by AstraZeneca
Awarded by NHMRC
This study was supported by an investigator initiated grant from AstraZeneca (D1443C00002). MB and CP were supported by NHMRC Senior Prinicipal Research Fellowships (IDs: 1059660, 628386). MY is supported by a NHMRC Senior Research Fellowship (1021973). SC is supported by a NHMRC Career Development Fellowship (1061998). KA is supported by a NHMRC Clinical Research Training Fellowship (628884).