Journal article

Hippocampal 5-HT1A Receptor and Spatial Learning and Memory

Yifat Glikmann-Johnston, Michael M Saling, David C Reutens, Julie C Stout

FRONTIERS IN PHARMACOLOGY | FRONTIERS MEDIA SA | Published : 2015

Abstract

Spatial cognition is fundamental for survival in the topographically complex environments inhabited by humans and other animals. The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5-hydroxytryptamine; 5-HT) receptor binding sites, particularly of the 1A receptor (5-HT1A) subtype. This review highlights converging evidence for the role of hippocampal 5-HT1A receptors in spatial learning and memory. We consider studies showing that activation or blockade of the 5-HT1A receptors using agonists or antagonists, respectively, lead to changes in spatial learning and memory. For example, pharmacological manipulation to induce 5-HT rel..

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