Journal article

Selenium-enriched Agaricus bisporus mushroom regulates colonic selenoprotein expression in rats differently under thermoneutral and hyperthermal stress conditions

Ken Ng, Kate Howell, Frank Dunshea, Tebo MASEKO

International Journal of Food and Nutritional Science | Ommega Online Publishers | Published : 2015

Abstract

Rats under thermoneutral conditions and fed mushroom-Se in dietary supplementation showed a significant fold increase (P<0.05) in mRNA expression relative to basal treatment (thermoneutral, control diet) of GPx-1 (2.98±0.82), GPx-2 (1.8±1.4), TrxR-1 (1.83±0.64) and SeP (2.77±0.92). Supplementation with α-tocopherol alone affected the expression of GPx-1 (1.83±0.82) and SeP (2.21±0.92). Rats subjected to heat stress and fed the control diet showed significant fold increase (P<0.05) in mRNA expression relative to the basal treatment of GPx-1 (3.15±0.82) and SeP (1.93±0.92). The expression of GPx-2 (3.2±1.4) and SeP (4.23±0.92) in rats fed mushroom-Se and expression of TrxR-1 (4.10±0.64) and Se..

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