Differences in the mechanism of blood clot formation and nanostructure in infants and children compared with adults

Abstract

Introduction Infants and children have a lower incidence of thrombosis compared with adults. Yet, the mechanism of blood clot formation and structure in infants and children, as the end product of coagulation, has not been studied. This study aimed to establish differences in the mechanism of thrombin generation, fibrin clot formation and response to thrombolysis in infants and children compared with adults. Materials and methods We studied thrombin generation, fibrin clot formation, structure and fibrinolysis in healthy infants, children and adults. Results Younger populations had a decreased potential to generate thrombin, at a slower velocity compared with adults, correlating positively w..