The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus
Wy Ching Ng, Sarah L Londrigan, Najla Nasr, Anthony L Cunningham, Stuart Turville, Andrew G Brooks, Patrick C Reading
JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2016
UNLABELLED: It is well established that influenza A virus (IAV) attachment to and infection of epithelial cells is dependent on sialic acid (SIA) at the cell surface, although the specific receptors that mediate IAV entry have not been defined and multiple receptors may exist. Lec2 Chinese hamster ovary (CHO) cells are SIA deficient and resistant to IAV infection. Here we demonstrate that the expression of the C-type lectin receptor langerin in Lec2 cells (Lec2-Lg) rendered them permissive to IAV infection, as measured by replication of the viral genome, transcription of viral mRNA, and synthesis of viral proteins. Unlike SIA-dependent infection of parental CHO cells, IAV attachment and infe..View full abstract
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Awarded by NHMRC, Australia
Awarded by National Health and Medical Research Council (NHMRC)
National Health and Medical Research Council (NHMRC) provided funding to Sarah Londrigan and Patrick Reading under grant number 1027545.The work was supported by grant 1027545 from the NHMRC, Australia.