Journal article

Assembly-Controlled Permeability of Layer-by-Layer Polymeric Microcapsules Using a Tapered Fluidized Bed

Ka Fung Noi, Ah Roozmand, Mattias Bjoernmalm, Joseph J Richardson, George V Franks, Frank Caruso

ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2015

Abstract

Nano- and microcapsules engineered through layer-by-layer (LbL) assembly are finding an increasingly large number of applications as catalysts, electrochemical biosensors, bioreactors, artificial cells and drug delivery vehicles. While centrifugation-based LbL assembly is the most common method for coating template particles and preparing capsules, it is a batch process and requires frequent intervention that renders the system challenging to automate and scale up. Here, we report the use of a tapered fluidized bed (TFB) for the preparation of multilayered polymer capsules. This is a significant improvement over our recent approach of fluidizing particles in cylindrical fluidized beds (CFB) ..

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project CE140100036) and the ARC under the Australian Laureate Fellowship (FL120100030) scheme, and by the Australian Government through an Australian Postgraduate Award (M.B.). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). The authors acknowledge Ray Dagastine, the University of Melbourne, for helpful discussions.